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Michal Bar-Oz on Muck Rack

Michal Bar-Oz

As seen in: BioRxiv
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Articles

GplR1, an unusual TetR-like transcription factor in Mycobacterium abscessus, controls the production of cell wall glycopeptidolipids, colony morphology, and virulence

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By Junpei Xiao, Manitosh Pandey, Juan M. Belardinelli, Michal Bar-Oz
| BioRxiv
Abstract Mycobacterium abscessus is a major human pathogen, mostly infecting people with pre-existing lung conditions such as cystic fibrosis. The production of glycopeptidolipids (GPL) is a major determinant of virulence of this bacterium, with clinical isolates that lack GPL generally exhibiting more aggressive clinical behavior. The current paradigm is that GPL production is abolished in vivo via irreversible, spontaneous mutations taking place as part of in-host evolution.
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