Michalis Barkoulas

Abstract Since Sydney Brenner’s foundational work in 1974, Caenorhabditis elegans has served as an impactful model for biological discovery primarily driven by genetic approaches, including mutagenesis-based screens and RNAi-based functional genomics. We discuss here how genetic screens in C.

Abstract The E2F family of transcription factors is conserved in higher eukaryotes and plays pivotal roles in controlling gene expression during the cell cycle. Most canonical E2Fs associate with members of the Dimerisation Partner (DP) family to activate or repress target genes. However, atypical repressors, such as E2F7 and E2F8, lack DP interaction domains and their functions are less understood. We report here that EFL-3, the E2F7 homologue of C.

Abstract Gene regulatory networks are fundamental in cellular decision-making, yet even in well-studied systems, their topologies are often poorly characterised. The nematode Caenorhabditis elegans contains a population of stem-like cells, known as seam cells. While seam cells are essential to generate the majority of the animal epidermis as well as specific neurons, the architecture of the underlying gene network has not been elucidated.