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Prenatal origin of NUTM1 gene rearrangement in infant B‐cell precursor acute lymphoblastic leukaemia
CONFLICT OF INTEREST STATEMENT Authors declare no competing financial interests in relation to the work described. Supporting Information Filename Description bjh19685-sup-0001-FigureS1.pptxPowerPoint 2007 presentation , 563.8 KB Figure S1. REFERENCES 1, . The expanding universe of NUTM1 fusions in pediatric cancer. Clin Transl Sci. 2023; 16(8): 1331–1339. 2, , , , , , et al.
The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome - Leukemia
Abstract KMT2A-rearranged acute lymphoblastic infant leukemia (KMT2A-r iALL) is associated with outsize risk of relapse and relapse mortality. We previously reported strong upregulation of the immediate early gene EGR3 in KMT2A::AFF1 iALL at relapse; now we provide analyses of the EGR3 regulome, which we assessed through binding and expression target analysis of an EGR3-overexpressing t(4;11) cell culture model. Our data identify EGR3 as a regulator of early B-lineage commitment.
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