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Michele Longoni Calió on Muck Rack

Michele Longoni Calió

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Articles

Neurovascular and inflammatory effects of biperiden in the acute phase of moderate traumatic brain injury: evidence from a non-human primate model

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By Viviam Sanabria, Matheus Braga, Luiz Eugênio Mello, Beatriz M. Longo, Christiane Gimenes, Simone Romariz, Amarildo Souza Gois, Michele Longoni Calió, Juliana Lima Willers, Maira L. Foresti
| Nature Verified
Abstract Traumatic brain injury (TBI) leads to extensive structural damage, neuronal loss, and functional deficits, along with marked disruption of cholinergic signaling and acute surges in acetylcholine. Biperiden, a muscarinic cholinergic antagonist, has emerged as a potential neuroprotective agent due to its ability to modulate synaptic plasticity and reduce excitotoxicity. Here, we evaluated the acute effects of biperiden in a translational non-human primate model of moderate TBI.
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