Michelle J

This study was conducted using data from the Rotterdam Study (RS). The design of the RS cohort has previously been described elsewhere [26]. Briefly, RS is a large prospective, population-based cohort study conducted among middle-aged and older people in the suburb Ommoord in Rotterdam, the Netherlands. The RS has four subcohorts, and participants (> 40) are followed every 3–5 years. The initial cohort (RS-I) started out in 1990 with 7983 participants aged 55 years and over.

An overview of the study workflow is presented in Fig. 1. The results described here and the full summary statistics are accessible through the miRNomics atlas (www.mirnomics.com). An overview of the study workflow Plasma levels of 2083 circulating miRNAs were measured (Additional file 1: Table S1) and genome-wide identification of miR-eQTLs was conducted in 2178 participants of the Rotterdam Study (Methods, Additional file 2: Fig. S1).

Chronic bone loss is an under-recognized complication of malaria, the underlying mechanism of which remains incompletely understood. We have previously shown that persistent accumulation of Plasmodium products in the bone marrow leads to chronic inflammation in osteoblast (OB) and osteoclast (OC) precursors causing bone loss through MyD88, an adaptor molecule for diverse inflammatory signals.