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Michelle Le He

As seen in: Nature, Wiley Online Library, Springer Nature, Texas Medical Center, Biological Psychiatry, UK Tech News (UKTN), Fintech Finance News

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Articles

Selective and differential roles of PVH CRH neurotransmitters in diet-induced obesity in mice

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By ZhiYing Jiang, Yuhan Cao, Michelle J. He, Michelle Le He, Cunjin Su, Runzhou Yang, Maojie Yang, Jing Cai, Shi-Bin Li, Hiroshi Yamaguchi, Luis de Lecea, Benjamin R. Arenkiel, Qingchun Tong
| Nature Verified
Abstract Stress and diet are known to synergistically promote risks of obesity but the underlying neural basis remains elusive. Corticotropin-releasing hormone neurons in the paraventricular hypothalamus (PVHCRH) are stress responsive and release both CRH and glutamate. Here we generated a mouse model with gain or loss of release in CRH or glutamate from PVHCRH neurons.
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mRNA vaccines engage unconventional pathways in CD8 + T cell priming

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By Suin Jo, Lijin Li, Chandrani Thakur, Kevin Telfer, Hussein Kareem Sultan, Ray A Ohara, Michelle J. He, Michelle Le He, Giri Nam, JING CHEN, Feiya Ou, Robert D. Schreiber, Gwendalyn J. Randolph, Naresha Saligrama, Theresa Murphy, William E. Gillanders, Kenneth M Murphy, Monia Draghi, Nicholas M. Valiante
| Nature Verified
Abstract Vaccines composed of mRNA and lipid nanoparticles (LNPs) activate B cells and T cells by inducing in vivo production of specific protein antigens. While B cells can be activated directly by antigens, T cell activation requires antigen processing and presentation by MHC molecules on specialized antigen-presenting cells (APCs).
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Dopaminergic Neurons in Zona Incerta Drives Appetitive Self-Grooming

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By ZhiYing Jiang, Michelle J. He, Michelle Le He, Claire Young, Jing Cai
| Texas Medical Center
Abstract Dopaminergic (DA) neurons are known to play a key role in controlling behaviors. While DA neurons in other brain regions are extensively characterized, those in zona incerta (ZITH or A13) receive much less attention and their function remains to be defined. Here it is shown that optogenetic stimulation of these neurons elicited intensive self‐grooming behaviors and promoted place preference, which can be enhanced by training but cannot be converted into contextual memory.
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