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Mick D Fellows

As seen in: Nature, Future Medicine
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Articles

SACF and GILA for in vitro transformation assessment of CRISPR/Cas9-edited cell therapy candidates: a multi-site study

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By Lena Dorsheimer, Joana Ferreira, Bojing Wang, Rebecca Bohnert, Sabine Kaiser, Louise Delsing, Benoit Fischer, Andreas Schulz, Connie Chen, Lucilia Pereira Mouriès, Mick D Fellows, Silvana Libertini, Rashade Haynes II, Andreas Neerincx, Corinna Smolarek, Stefanie Könen, Kyle L. Kolaja, Ridhirama Bhuwania, Myriam Lemmens
| Nature Verified
Abstract Tumorigenicity is a key safety concern for CRISPR/Cas9-based gene therapies, yet its assessment remains challenging due to the lack of relevant and sensitive in vivo models. This HESI Global multi-site study evaluated the Soft Agar Colony Formation (SACF) assay and the Growth in Low Attachment (GILA) assay for in vitro transformation testing of CRISPR/Cas9-edited cells as part of tumorigenicity risk assessment.
Open in Who Shared Issue with article?

Targeting safety in the clinic for precise genome editing using CRISPR: a genotoxicologist's perspective

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By Mick D Fellows
| Future Medicine Verified
Targeting safety in the clinic for precise genome editing using CRISPR: a genotoxicologist's perspective
Open in Who Shared Issue with article?
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