Microbiota-Host Interaction

ARG antimicrobial resistance genes CFU colony forming unit ECM extracellular matrix FBS fetal bovine serum H&E haematoxylin and eosin MIC minimal inhibitory concentration TSB tryptic soy broth VLU venous leg ulcers WGS whole-genome sequencing 1 INTRODUCTION Venous leg ulcers (VLUs) represent the most common chronic wound that arises as a complication from venous insufficiency, affecting millions of patients with billions of dollars of healthcare costs annually.

AOPP advanced oxidation protein products AUC area under the curve DRG dorsal root ganglia MDA malondialdehyde MIA monoiodoacetate NSAIDs nonsteroidal anti-inflammatory drugs OA osteoarthritis PAB pro-oxidant–antioxidant balance PWT paw withdrawal thresholds qRT-PCR quantitative real-time PCR Tac1 Tachykinin 1 TOS total oxidant status What is already known The treatment of pain in osteoarthritis is limited by inadequate efficacy/tolerability of available medications.

Chronic lung diseases are a major and increasing global health problem, commonly caused by cigarette smoke. We aimed to explore the antioxidant effects of lactic acid bacteria (LAB) against cigarette smoke in bronchial epithelial cells. The antioxidant effects of 21 heat-killed (HK) LAB strains were tested in cigarette smoke stimulated BEAS-2B cells and 3-D bronchospheres organoids.