Miho Mukai on Muck Rack

Miho Mukai

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Articles

Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris

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By Miho Mukai, Hayato Takahashi, Yoko Kubo, Yasuhiko Asahina, Hisato Iriki, Hisashi Nomura, Hiromi Ito, Yutaka Kurebayashi, Jun Yamagami, Norihisa Mikami, Shimon Sakaguchi, Masayuki Amagai, Yasuhiko Asahina, Aki Kamata
| Science Magazine Verified
Editor’s summary A challenge in the development of cell therapies for many autoimmune diseases is the difficulty of achieving antigen specificity, often resulting in therapies that nonspecifically target broad swaths of the immune system and leave patients in an immunocompromised state.
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HIVEP1 aggravates NASH by reprogramming polyamine metabolism in TH17 cells

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By Yidan Ren, Giulia De Rossi, Xiaoyan Liu, Miho Mukai
| Science Magazine Verified
Editor’s summary Immune cells, specifically T helper 17 (TH17) cells, have been associated with nonalcoholic steatosis (NASH); however, the underlying mechanisms were not clear. In Ren et al., the authors performed single-cell assay for transposase accessible chromatin sequencing (scATAC-seq) on liver immune cells from mice with NASH symptoms. TH17 cells were the most abundant.
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