Mihue Jang on Muck Rack

Mihue Jang

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Articles

Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy

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By Joo-Yoon Chung, Jisu Hong, Dahye Lee, Sangwon Yoon, Seung-Hwan Lee, Yujin Jung, Song Cheol Kim, Chang-Han Lee, Su-Min Yee, Seung Hun Shin, Mihue Jang
| Nature Verified
Abstract Chimeric antigen receptor (CAR)-based immunotherapies against solid tumors face two major hurdles, the “decoy effect” of shedding antigens that sequester CARs, and the limited persistence of immune effectors within the immunosuppressive tumor microenvironment. Here, we present a mechanistic approach to overcome these barriers by integrating a physiologically relevant screening platform with circular RNA (circRNA) engineering.
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