Mika Ito

Abstract Alzheimer's disease begins with Abeta accumulation, progresses to tau aggregates and results in widespread neurodegeneration (1-3). Simultaneous propagation of Abeta aggregates from very limited to wide and distant brain regions is one of the outstanding events in the early stage.

The U.S. Patent and Trademark Office (USPTO) issued Guidance this week on how to evaluate patent inventorship when technology is developed using artificial intelligence (AI) systems, including generative AI. Companies developing and utilizing AI should understand the role human engineers and scientists play in working with AI tools and developing new technologies to ensure their research and development efforts continue to be adequately protected through the U.S. patent system.

Discussion Studies have shown that childhood obesity is a factor in subsequent non-communicable diseases,18 and several epidemiological studies have suggested that this theory can also be applied to Japanese children.19–22 However, it has been reported that the growth status of children born to immigrant mothers differs from that of the children born to native mothers, making it a health challenge in the destination country.