Mikael Boden on Muck Rack

Mikael Boden

As seen in: Nature
Group leader Bioinformatics at the University of Queensland
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Articles

Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins - Nature Communications

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By Yu Shang Low, Gabriel Foley, Jason Low, Tristan I. Croll, J. Shaun Lott, Evelyne Deplazes, Mikael Boden, Mark Hurst, Sarah Piper, Solace G. Roche, Nadezhda A. Aleksandrova
| Nature Verified
Abstract ABC toxins are toxin-translocating, pore-forming proteins found in a wide range of insecticidal bacteria and some mammalian pathogens. The Yersinia entomopahaga toxin complex (YenTc) belongs to a distinct subclass of ABC toxins, defined by a divergent molecular architecture. Structural details that define their mechanism of action remain to be elucidated.
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Multilingual model improves zero-shot prediction of disease effects on proteins

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By Ruyi Chen, Nathan J Palpant, Gabriel Foley, Mikael Boden
| biorxiv.org
Abstract Models for mutation effect prediction in coding sequences rely on sequence-, structure-, or homology-based features. Here, we introduce a novel method that combines a codon language model with a protein language model, providing a dual representation for evaluating effects of mutations on disease.
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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure - Nature Communications

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By Sophie W Shen, Sakurako Kobayashi, Zezhuo Su, Qiongyi Zhao, Sumedha Negi, Joseph Powell, Sally L. Dunwoodie, Mikael Boden, Quan Nguyen
| Nature Verified
Abstract Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across developmental lineages. Here, we engineer barcoded induced pluripotent stem cells to generate an atlas of multilineage differentiation from pluripotency, encompassing an eight-day time course with modulation of WNT, BMP, and VEGF signalling pathways.
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