Mikayla Brown

Abstract The accumulation of misfolded proteins underlies a broad range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Due to their dynamic nature, these misfolded proteins have proven challenging to target therapeutically. Here, we specifically target misfolded disease variants of the ALS-associated protein superoxide dismutase 1 (SOD1), using a biological proteolysis targeting chimera (BioPROTAC) composed of a SOD1-specific intrabody and an E3 ubiquitin ligase.

Published Sunday, October 19, 2025 By Mikayla Brown, NCCU Athletic Communications DURHAM - For Nasim Cosby, football has always been more than just a game. It's been a lifelong journey shaped by resilience, family support and an unwavering belief in himself. The Plainfield, New Jersey, native first picked up a football at 5 years old. He began his journey as a quarterback until a shoulder injury changed his path.