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Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells - Nature Communications
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-47424-z, published online 12 April 2024 In this article the title was incorrectly written as ‘Semmaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells’ but should have been ‘Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells’. The original article has been corrected.
Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells - Nature Communications
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Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not completely understood. Here we demonstrate that Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 are upregulated on stimulated CD8+ T cells, allowing tumour-derived SEMA3A to inhibit T cell migration and assembly of the immunological synapse.
By Yale Michaels, Philip Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna A. Kulicke, Vitul Jain, Victoria Woodcock, Huw Colin-York, Andreas V Hadjinicolaou, Julie M. Mazet, Joshua A. Bull, Christopher Pugh, Alain Townsend, Audrey Gerard, Lars R. Olsen, Michael L. Dustin, E. Yvonne Jones, Mike B. Barnkob, Gracie-Jennah Mead
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