Mike Barbeck

Keywords: Lymphocytes biomaterials foreign body response tissue regeneration immunomodulation review Introduction The implantation of any biomaterial triggers a highly orchestrated sequence of host reactions, collectively referred to as the foreign body response (FBR). This cascade begins within seconds after implantation with the adsorption of plasma proteins and the formation of a provisional matrix composed of fibrin, fibronectin, and immunoglobulins.

Keywords: Granulocytes biomaterials foreign body response tissue regeneration immunomodulation review Introduction Every biomaterial implanted into the human body elicits a specific cellular and tissue response, commonly referred to as the foreign body response to biomaterials (1, 2). This response includes injury, blood–material interactions, provisional matrix formation, and acute as well as chronic inflammation.

Keywords: Biocompatibility biomaterial medical device chicken chorioallantoic membrane (CAM) histopathology scoring DIN ISO 10993-6 3R-concept Introduction The development of a new medical device or biomaterial and its introduction into the market requires extensive testing procedures for safety and clinical performance.