Mila Brum Ortigoza on Muck Rack

Mila Brum Ortigoza

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Articles

Targeting host sialic acids in the upper respiratory tract with a broadly-acting neuraminidase to inhibit influenza virus transmission

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By Mila Brum Ortigoza, Stacey Bartlett, Catherina L Mobini, Hedy L Rocha
| biorxiv.org
New Results doi: https://doi.org/10.1101/2023.06.02.543524 Abstract The ongoing transmission of influenza A viruses (IAV) for the past 100 years continues to be a burden to humans. IAV binds terminal sialic acids (SA) of sugar molecules present within the glycocalyx of the upper respiratory tract (URT) in order to successfully gain entry and infect hosts. The two most common SA structures that are important for influenza virus infection and tropism are those with α2,3- and α2,6- linkages.
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An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae

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By Mila Brum Ortigoza, Simone B. Blaser, M. Ammar Zafar, Alexandria J. Hammond
| American Society for Microbiology (ASM)
Research Article | Host-Microbe Biology Mila Brum Ortigoza, Simone B. Blaser, M. Ammar Zafar, Alexandria J. Hammond, Jeffrey N. Weiser Keith P. Klugman, Editor DOI: 10.1128/mBio.02359-18 ABSTRACT The pandemic potential of influenza A viruses (IAV) depends on the infectivity of the host, transmissibility of the virus, and susceptibility of the recipient.
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