Millicent N. Ekwudo

Anthony J. Hannan and Carolina Gubert contributed equally to this work. S. K., M. N.Ekwudo, D.Lu, et al. 2026. “Inhibition of the NLRP3 Inflammasome With MCC950 Improves Gut Health in Huntington's Disease Mice.” Journal of Neurochemistry170, no. 4: e70419. Sarkar, https://doi.org/10.1111/jnc.70419. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data will be available on request.

AD Alzheimer's disease ASV amplicon sequence variant ATP adenosine triphosphate bp base pair CAG cytosine-adenine-guanine CAPS cryopyrin-associated periodic syndromes CFC cued fear conditioning CLMM cumulative link mixed model CS conditioned stimulus DNA deoxyribonucleic acid EDTA ethylenediaminetetraacetic acid F primers forward primers FITC fluorescein isothiocyanate GI gastrointestinal GLM generalised linear model GLMM generalised linear mixed model GSDMD gasdermin D GTT gut transit time...

Keywords progressive MS gut microbiome metabolomics MRI disease progression fatty acids microbial metabolites Introduction Multiple studies have identified abnormalities in the gut microbiome in multiple sclerosis (MS).1,2,3,4,5,6,7,8,9,10,11,12 Intestinal microbes and their metabolites are known to influence a wide variety of processes related to both health and disease.13,14,15,16,17 In terms of MS, a major question is the manner in which intestinal microbes and their metabolites are...