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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Microfluidic artery-on-a-chip model with unidirectional gravity-driven flow for high-throughput applications
Microfluidic artery-on-a-chip model with unidirectional gravity-driven flow for high-throughput applications† Cardiovascular disease (CVD) is the leading cause of death worldwide, with a noticeable decline in the approval of new therapeutic interventions. Currently, there is no gold standard for developing new therapies for CVDs, and preclinical models do not translate to clinical efficacy. Therefore, there is an urgent need for in vitro models that more accurately mimic human disease processes.
Breaking barriers: the fungal toxin candidalysin disrupts epithelial integrity and induces inflammation in a gut-on-chip model
Abstract Candida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract, vagina, and mouth of healthy humans. Under certain conditions, it can become invasive, causing mucosal or life-threatening systemic infections. One mechanism used by C.albicans to breach the epithelial barrier is the secretion of candidalysin, a cytolytic peptide toxin.
Mycotoxin candidalysin impairs epithelial barrier integrity and initiates inflammation in a gut-on-chip model
Abstract Candida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract, vagina, and oral cavity of healthy humans. Under certain conditions, it can become invasive, causing mucosal or life-threatening systemic infections. One mechanism used by C.albicans to breach the epithelial barrier is the secretion of candidalysin, a cytolytic peptide toxin.
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