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Min-Ying Lin

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Articles

Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer

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By Chun-Yi Wu, Liang-Cheng Chen, Min-Ying Lin, Jyh-Der Leu, Yi-Jang Lee
| Nature Verified
Abstract Metastasis is a major contributor to the mortality and morbidity of human non-small cell lung cancer (NSCLC), driven by actin cytoskeletal rearrangements that enhance cancer cell motility and invasiveness. Cofilin-1 (CFL-1), a key actin-binding protein regulated by LIM kinase (LIMK), controls actin turnover through phosphorylation at serine-3. However, the role of CFL-1 phosphorylation in lung cancer metastasis remains unclear.
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