Ming-yan Zhu on Muck Rack

Ming-yan Zhu

As seen in: Nature
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FLRT2 promotes foam cell formation and atherosclerosis by inhibiting USP22-mediated ABCA1 deubiquitination

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By Jie Wang, Yan-Yu Chen, Juan Peng, Hong Gao, Jing-quan Zhou, Hui-xuan Zhang, Li-zhen Guo, En-dong Jiang, Yuan-hong Sun, Ming-yan Zhu, Jian-ye Peng, Gao-feng Zeng, Yuan-ye Dang, Kong-yang Ma, Xiao-yan Dai
| Nature
Abstract Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of foam cells within the arterial wall. Despite substantial progress, the molecular mechanisms governing foam cell formation remain incompletely understood. Here, we identify fibronectin leucine-rich transmembrane protein 2 (FLRT2) as a previously unrecognized regulator of macrophage-driven atherogenesis through the facilitation of foam cell formation.
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