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Mingchen Yin on Muck Rack

Mingchen Yin

As seen in: Nature
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Articles

Deltex E3 ubiquitin ligase 2 potentiates STING-mediated type I interferon response by K63-linked ubiquitination

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By Zhuang Liu, Runze Li, Caihong Fan, Yuheng Liu, Jia Liu, Mingchen Yin, Xudong WANG, Zhi Qi, Yanna Shen, Chang Liu, Ni Shang
| Nature Verified
Abstract Stimulator of interferon genes (STING) signaling, as a pivotal DNA-sensing mechanism, orchestrates antiviral and antitumor immunity through the induction of type I interferon response. Precise modulation of STING signaling is critical for maintaining immune homeostasis, yet its regulatory landscape has not been fully elucidated. Here, we identify the Deltex E3 ubiquitin ligase 2 (DTX2) as a positive regulator of STING-type I interferon response.
Open in Who Shared Issue with article?

Deltex E3 ubiquitin ligase 2 prevents sepsis-induced myocardial injury through degrading TfR1 via promoting K27-linked ubiquitination - Cell Death & Differentiation

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By Chang Liu, Jia Liu, Runze Li, Caihong Fan, Yixing Chen, Lihong Guo, Zhi Qi, Yanna Shen, Mingchen Yin
| Nature Verified
Abstract Sepsis, a life-threatening systemic inflammatory condition, frequently leads to myocardial injury-a complication for which current therapeutic strategies demonstrate limited efficacy. Here, we explored the potential role and therapeutic implications of Deltex E3 ubiquitin ligase 2 (DTX2) in sepsis-induced myocardial injury. Our results demonstrated that DTX2 expression was significantly upregulated in septic patients, mice models, and lipopolysaccharide (LPS)-stimulated cardiomyocytes.
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