Insulin critically regulates metabolic enzyme expression in hepatocytes to maintain glucose and lipid homeostasis.1 Dysregulation of this process, characterized by insulin resistance, is a fundamental contributor to the development of type 2 diabetes (T2D).2,3,4 Though some studies have assumed a uniform response of hepatocytes to insulin,5,6,7 single-cell transcriptomics demonstrates that about half of hepatocyte genes are preferentially expressed in zones proximal to either the portal or...
