Mingshui Chen on Muck Rack

Mingshui Chen

As seen in: Journal of Translational Medicine
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Articles

Cisplatin-mediated activation of NF-κB promotes lung cancer stem cell formation via DNA repair pathways - Journal of Translational Medicine

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By Qiumei Li, Chunjiang Liu, Shizhong Wu, Ling Wang, Guibin Weng, Mingshui Chen, Wansong Lin
| Journal of Translational Medicine Verified
To measure DNA damage response in DDP-resistant lung adenocarcinoma, A549 cells were exposed to DDP for 2 h (using the optimized dose determined in Figure S1). This treatment transiently upregulated γ-H2AX, a well-established biomarker of DNA double-strand breaks (DSBs) [22]. The subsequent decrease in γ-H2AX levels after removing DDP demonstrated an efficient DNA repair response in these cells (Fig. 1A-B).
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