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Mingshui Wang

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Articles

Redox‐Regulated Conformational Change of Disulfide‐Rich Assembling Peptides

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By Huilei Dong, Mingshui Wang, Shihui Fan, Chuanliu Wu
| Wiley Online Library Verified
Abstract Disulfide bond formation is usually used in nature for the regulation and stabilization of protein conformations. This principle has now been expanded to control the conformational change of thiol-rich peptides into an amphiphilic β-hairpin conformation, which undergoes a subsequent self-assembly to form a mechanically rigid hydrogel. Such a stimuli-responsive feature allows the biomedical application of such peptides.
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