Minguell Domingo on Muck Rack

Minguell Domingo

As seen in: Frontiers, Thorax
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Articles

Novel frameshift variants expand the map of the genetic defects in IRF2BP2

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By Paz Gandiaga, Minguell Domingo, Immunodeficiencies Unit, Ocejo Vinyals
| Frontiers
1 Introduction The IRF2BP (interferon regulatory factor-2 binding protein) family is composed of two members, IRF2BP1 and IRF2BP2, characterized by a C-terminal repression domain. These proteins have been reported to act as nuclear transcriptional corepressors that are activated during IRF2 binding, which induces a conformational change in the DNA binding domain and the C-terminal region of IRF2 (1).
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