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Articles by Mingwei Wei
Dissociation between humoral and multi-omic immune responses to inactivated COVID-19 vaccination in patients with pulmonary tuberculosis
Abstract Introduction: Patients with pulmonary tuberculosis (PTB) may experience persistent immune dysregulation during anti-tuberculosis treatment, yet vaccine evaluation in this population has largely relied on humoral endpoints. Whether preserved antibody responses reflect coordinated systems-level immune activation after inactivated COVID-19 vaccination remains unclear. This study used systems vaccinology to identify multi-omic immune signatures induced by vaccination in PTB patients.
The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
Abstract In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-blind, phase 3 trial (ChiCTR2300076253) evaluated the efficacy and safety of LZ901 in adults ≥40 years.
Hemostatic agent use and symptomatic anastomotic leakage in colorectal cancer patients with postoperative abdominal bleeding: a hypothesis-generating study
Abstract The association between postoperative abdominal bleeding (POAB) and anastomotic leakage (AL) after colorectal cancer surgery remains unclear, and whether hemostatic therapy would increase AL risk in POAB patients is understudied. We retrospectively analyzed 9651 patients who underwent colorectal resection with anastomosis (2010–2023). Logistic regression models were used to assess the association between POAB and symptomatic AL.
Vaccines | Free Full-Text | Immunogenicity, Safety, and Immune Persistence of One Dose of SARS-CoV-2 Recombinant Adenovirus Type-5 Vectored Vaccine in Children and Adolescents Aged 6-17 Years: An Immunobridging Trial
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LINC00707 impairs the Natural Killer cell antitumour activity in hepatocellular carcinoma through decreasing YTHDF2 stability
1 INTRODUCTION On a global scale, hepatocellular carcinoma (HCC) stands at the fifth position in terms of cancer incidence and holds the third position for cancer-related mortality.1, 2 Although there have been notable advancements in treatments such as surgery, radiofrequency ablation, transarterial chemoembolization, targeted therapy and emerging immunotherapies, there is still potential for improving the survival rates of HCC patients.3-5 Therefore, there is an urgent demand for a novel...
Frontiers | Immunogenicity and safety of an Escherichia coli-produced 9-valent human papillomavirus vaccine (types 6/11/16/18/31/33/45/52/58) in healthy Chinese women aged 20-45 years: a single-center, randomized, observer-blinded, positive controlled pha
CLINICAL TRIAL article Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1706662 1 Introduction The human papillomavirus (HPV) causes premalignant and malignant lesions of the cervix, vagina, vulva, anus, penis, and oropharynx as well as genital warts, which has imposed a substantial disease burden worldwide, especially in developing countries (1, 2). Cervical cancer is the fourth most common cancer among women.
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