Li Zhang on Muck Rack

Li Zhang

As seen in: Environmental Health Perspectives, Illumination, Medium, National Institutes of Health, Emerging Infectious Diseases Journal, Nature, Wiley Online Library, Yahoo Canada, Ageing & Society, Cambridge University Press & Assessment and
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Articles

Supine hypertension as a distinct phenotype of neurogenic orthostatic hypotension with relatively preserved clinical function in Parkinson’s disease

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By Yihong Song, Bo Shen, Shuangshuang Dong, Xiuxiu Hu, Haiying Zhang, Dongfeng Li, Jun Zhu, Xu Jiang, Li Zhang
| Nature Verified
Abstract Supine hypertension (SH) frequently co-occurs with neurogenic orthostatic hypotension (nOH) in Parkinson’s disease (PD), yet its clinical characteristics and autonomic status remain unclear. By comparing PD patients with coexisting nOH and SH against those with isolated nOH, we found that the PDOH + SH+ group displayed better cognitive function, lower burden of non-motor symptoms, and a higher quality of life.
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Molecular mechanisms of mitochondrial Ca 2+ exchanger NCLX

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By Li Zhang, Weizhong Zeng, Jing XUE, Yan Wang, Youxing Jiang
| Nature Verified
Abstract Mitochondrial Ca²⁺ homeostasis is maintained through coordinated influx and efflux processes, with NCLX long recognized as the primary Ca²⁺ extruder operating via Na⁺/Ca²⁺ exchange. Here, we report cryo-EM structures of rat NCLX in cytosolic-facing occluded and open states. The central transmembrane (TM) domain of NCLX comprises ten helices arranged in two inverted, structurally similar halves, with two α-repeats forming a central ion-binding pocket.
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Aneuploidy selects for the acquisition of driver genes in breast cancer

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By Khalid N Al-Zahrani, Jocelyn Nurtanto, Andreea Obersterescu, Katie Teng, Christopher Lowden, Lauren Caldwell, Miguel A. Pérez-Castro, Ricky Tsai, Alexander T Bahcheli, Shifei Wu, Masahiro Narimatsu, Iosifina Fotiadou, Kin Chuah Chan, Linkang Zhang, K. W. Annie Bang, Michael Parsons, Larissa Mourao, Palavalasa Sravya, Li Zhang, Peter Sajjakulnukit, Costas A. Lyssiotis, Alexander D. Borowsky, Colinda L. G. J. Scheele, Daniel Wahl, Hartland W. Jackson, Katherine Stewart, Elaine Fuchs, Sean Egan, Miguel Angel Pujana, Jüri Reimand, Jeffrey L. Wrana, Daniel Schramek, Ellen R. Langille, Julien Dessapt, Cynthia H. Chiu, Geraldine Mbamalu, Adele G. Lopes, E. Idil Temel, Liddy McCulla
| Nature Verified
Abstract Chromosome instability is highly prevalent in cancer and drives large-scale chromosomal imbalances, known as aneuploidies1,2,3,4. How aneuploidy contributes to tumorigenesis remains difficult to study due to the vast numbers of genes affected. Here we established a CRISPR knockout- and activation-linked assay (CRISPR-KOALA), enabling high-throughput bidirectional genetic screens in immunocompetent mouse models of cancer.
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