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Articles by Mingyang Ding
Bacterial extracellular vesicles from Streptococcus mutans drive OSCC progression through β-catenin signaling
Abstract Oral squamous cell carcinoma (OSCC) is an aggressive malignancy in which microbial dysbiosis is increasingly recognized as a contributing factor, yet the pathogenic potential of bacterial extracellular vesicles (EVs) remains poorly defined. To determine whether Streptococcus mutans–derived EVs (SmEVs) influence OSCC progression, we isolated and characterized SmEVs from ATCC 35,668 and examined their effects in CAL-27 cells and a nude-mouse xenograft model.
Coupling Water Purification and Carbon Sequestration at Various Spatial Scales From Supply and Demand Perspective
1 Introduction Ecosystem services (ESs) bridge natural and socioeconomic systems through the mechanisms of supply and demand. ES-supply represents the total quantity of services and products, reflecting the “structure-process-function-service/product” chain within natural systems (Boyd and Banzhaf 2007), which is constrained by the spatiotemporal distribution of ecosystems and inherent capacity to provide services.
Carbon Stock and Environmental Variations of Typical Plantations in Mufu Mountain in Hubei Province, China
1 Introduction Forest ecosystems constitute the largest reservoir of terrestrial organic carbon in the biosphere, playing a fundamental role in regulating the global carbon cycle and mitigating climate change (Zou et al. 2023). Carbon stock of forest and soil serves as a critical indicator of ecosystem service functionality and is key for achieving the strategic objectives of carbon peak and carbon neutrality (Li et al. 2023).
Evaluation of the Pathogenesis and Virulence of Highly Virulent Eurasian Genotype Ⅱ African Swine Fever Virus with MGF505-2R Gene Deletion in Piglets
Submitted: 24 September 2025 Posted: 28 September 2025 You are already at the latest version Background: African swine fever virus (ASFV) poses a significant threat to the global pig industry due to its high mortality rates and complex genetic variation. Live attenuated vaccines (LAVs) have shown promise in providing protection against ASFV. In our previous study, MGF505-2R was identified as a potent inhibitor of innate immunity in vitro.
Iron overload causes macrophages to produce a pro‐inflammatory phenotype in the synovium of hemophiliac arthritis via the acetyl‐p53 pathway
Haemophiliac arthritis (HA) is caused by spontaneous intra-articular hemorrhage and repeated intra-articular hematomas, leading to iron overload, which, in turn, induces M1 macrophage polarisation and inflammatory cytokine secretion, resulting in synovitis. Here, we explored the mechanism by which iron overload in HA induces the polarisation of M1 macrophages, providing a new approach for the treatment of HA synovitis.
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