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Articles by Mingyu He
Baicalin improves the inflammatory response of RA-FLS by targeting the circ_0000734/miR-197-5p/IKBKB axis
Abstract Background: Rheumatoid arthritis (RA) is a chronic autoimmune and inflammatory disease, and circular RNAs (circRNAs) are widely involved in its progression. Baicalin, a naturally derived small molecule, has been shown to improve inflammatory responses in RA by regulating circRNAs; however, the underlying regulatory mechanism remains unclear.
Frontiers | Xinfeng capsule improves hyperinflammation-associated hypercoagulability and self-perception in osteoarthritis by regulating KLF4 through METTL14-mediated m6A modification of lncRNA MEG3
First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China Background: Our previous studies have demonstrated that Xinfeng Capsule (XFC) exerts therapeutic effects on hyperinflammation-associated hypercoagulability and self-perception of patients (SPP) with osteoarthritis (OA). However, the underlying molecular mechanisms remain unclear.
Ferroptosis: New strategies for clinical treatment of rheumatoid arthr
Back to Journals » Journal of Inflammation Research » Volume 18 Authors Sun Y, Liu J , He M, Huang D, Wang Y Received 18 February 2025 Accepted for publication 1 May 2025 Published 21 May 2025 Volume 2025:18 Pages 6529—6541 DOI https://doi.org/10.2147/JIR.S523410 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Professor Ning Quan Yanqiu Sun, Jian Liu, Mingyu He, Dan Huang, Yuan Wang Department of Rheumatology and...
Exploring the therapeutic potential of FSGTC for osteoarthritis: a com
Back to Journals » Drug Design, Development and Therapy » Volume 19 Authors He M, Liu J , Gao W, Sun Y, Chen X, Fang Y Received 5 February 2025 Accepted for publication 8 June 2025 Published 17 June 2025 Volume 2025:19 Pages 5123—5141 DOI https://doi.org/10.2147/DDDT.S517935 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Solomon Tadesse Zeleke Mingyu He,1 Jian Liu,1 Wu Gao,2 Yanqiu Sun,1 Xiaolu Chen,1 Yanyan Fang1...
"CD5 Expression by Dendritic Cells Directs T Cell Immunity and Sustains" by Mingyu He, Kate Roussak et al.
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c+CD5+ DCs are reduced in melanoma-affected lymph nodes, with CD5 expression on DCs correlating with patient survival. Activating CD5 on DCs enhanced T cell priming and improved survival after ICB therapy.
FSGT capsule inhibits IL‐1β‐induced inflammation in chondrocytes and ameliorates osteoarthritis by upregulating LncRNA PACER and downregulating COX2/PGE2
1 INTRODUCTION Osteoarthritis (OA), a chronic and degenerative joint disorder in the elderly population, is characterized by progressive cartilage destruction and subcartilage bone hyperplasia,1 causing joint pain and stiffness.2 The prevalence of OA is rising due to the growing aging of the population. Although OA affects both men and women, women are more likely to be symptomatic.
Rational design of Lewis base molecules for stable and efficient inverted perovskite solar cells
Information Published In Science Volume 379 | Issue 6633 17 February 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License. Submission history Received: 16 August 2022 Accepted: 13 January 2023 Published in print: 17 February 2023 Permissions Request permissions for this article.
Ultralow frictional healing explains recurring slow slip events
LATEST NEWS Silently not able to heal Faults on the Earth rupture over time but do not always produce earthquakes. Such aseismic, or slow slip, events are an important way to release stress. Shreedharan et al. determined the frictional healing properties of a slow slip portion of the Hikurangi fault in New Zealand. They found that the ability of the material to strengthen after failure was limited, unlike for earthquake-producing events.
Continuous-flow electrosynthesis of ammonia by nitrogen reduction and hydrogen oxidation
LATEST NEWS Protons from H2 for ammonia synthesis Electrochemical synthesis of ammonia from nitrogen (N2) and hydrogen (H2) could advantageously decentralize the current mass production of fertilizer. One promising method being explored involves lithium ion cathodic reduction in an organic solvent electrolyte, followed by reaction of the lithium with N2. However, conventional H2 oxidation catalysts for the complementary anodic process are unstable in these conditions. Fu et al.
Dynamic kinetic asymmetric arylation and alkenylation of ketones
LATEST NEWS Nickel’s dual role in ketone transformation Adding carbon nucleophiles to ketones is a common route to tertiary alcohols. When those ketones have a chiral center adjacent to the carbonyl, it is possible in principle to use a base to dynamically epimerize that center and thereby achieve enantioconvergent production of just one tertiary alcohol diastereomer. That approach has nonetheless proven challenging in practice. Ruan et al.
Menin “reads” H3K79me2 mark in a nucleosomal context
LATEST NEWS A reader for H3K79me2 Decoding a histone modification requires identification of proteins that “read” the mark. Methylation of histone H3 lysine-79 (H3K79) plays key roles in gene regulation, but it remains a mystery how this histone mark is recognized and interpreted by specific readers. Lin et al. identified the protein menin as a bona fide reader of H3K79me2 using a multifunctional nucleosome-based photoaffinity probe.
Response to comment on “Sexual selection promotes giraffoid head-neck evolution and ecological adaptation”
LATEST NEWS Abstract Hou et al. challenged the giraffoid affinity of Discokeryx and its ecology and behavior. In our response we reiterate that Discokeryx is a giraffoid that, along with Giraffa, shows extreme evolution of head-neck morphologies that were presumably shaped by selective pressure from sexual competition and marginal environments. SIGN UP FOR THE SCIENCE eTOC Get the latest table of contents from Science delivered right to you! Hou et al.
Comment on “Sexual selection promotes giraffoid head-neck evolution and ecological adaptation”
LATEST NEWS Abstract Wang et al. (Research Articles, 3 June 2022, eabl8316) reported an early Miocene giraffoid that exhibited fierce head-butting behavior and concluded that sexual selection promoted head-neck evolution in giraffoids. However, we argue that this ruminant is not a giraffoid and thus that the hypothesis that sexual selection promoted giraffoid head-neck evolution is not sufficiently supported.
The extracellular matrix and the immune system: A mutually dependent relationship
LATEST NEWS Immune cells in the extracellular matrix The extracellular matrix is a dynamic tissue support network that is made up of components including fibrillar proteins, glycosaminoglycans, proteoglycans, and mucus. There is growing knowledge that this network has an intricate relationship with immune cells, which has important implications for our understanding of host defense, wound repair, fibrotic disease, and aging. Sutherland et al.
A tunable reflector enabling crustaceans to see but not be seen
LATEST NEWS A photonic glass to camouflage crustaceans Eye pigments are usually required for vision, but for creatures that want to stay hidden, they make it easier to be seen by others. This raises the question how marine invertebrates avoid being detected. Studying larval crustaceans, Shavit et al. found that many of these animals use an ultracompact reflector that overlies the opaque eye pigments and conceals them from view (see the Perspective by Feller and Porter).
Decoding foreign antigen tolerance
The ability to distinguish between self and nonself is a fundamental function of the immune system. Yet, in a few special situations, nonself antigens must be safely harbored in the body. This phenomenon of immunotolerance is crucial for the placenta, where the fetal genome is safe from attack by the maternal immune system. It is also relevant in the testis, where the synthesis of meiosis-associated neoantigens occurs during puberty after the establishment of self-tolerance.
Photonic tinkering in the open ocean
LATEST NEWS Abstract Billions of animals living in open water, or pelagic habitats, can disappear into their surroundings using a variety of light-manipulating camouflage solutions. These include transparent, antireflection, and glittery reflective structures. Although such photonic camouflage allows these animals to vanish into their surroundings, they still need to eat (and avoid being eaten), which requires the ability to detect their invisible neighbors.
Farming in arid areas depletes China’s water
Information & Authors Information Published In Science Volume 379 | Issue 6633 17 February 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission history Published in print: 17 February 2023 Permissions Request permissions for this article.
The first dedicated ice giants mission
Uranus and Neptune are commonly called ice giants because they have a greater percentage of heavy elements compared to the gas giants, Jupiter and Saturn. The only spacecraft to visit Uranus and Neptune was Voyager 2 with brief flybys in 1986 and 1989—more than 30 years ago. These encounters presented a captivating view of two exotic planetary systems, leaving more questions than previously imagined.
Precision immunotherapy
GRAND PRIZE WINNER Aleksandar Obradovic Aleksandar Obradovic received undergraduate degrees in Biology and Computer Science from Columbia University, where he continued as an MD and PhD and received his PhD in the Department of Systems Biology in 2021. While working to complete his MD training, Aleksandar started his laboratory with an appointment as an associate research scientist in the Department of Medicine at Columbia in 2022.
Ethical and legal wastewater surveillance
Information & Authors Information Published In Science Volume 379 | Issue 6633 17 February 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission history Published in print: 17 February 2023 Permissions Request permissions for this article.
Searching for common ground
In the mid-1960s, while studying patients with respiratory symptoms, two pairs of scientists discovered a new type of virus unlike any they had seen before in humans ( 1 , 2 ). These viruses were later given the name “coronaviruses” owing to spike-like projections on the surface that were reminiscent of the solar corona. In the following decades, other human-infecting coronaviruses were identified, along with a wide variety of coronaviruses that infect birds and mammals ( 3 ).
Possible psychedelic therapeutic mechanism
Information Published In Science Volume 379 | Issue 6633 17 February 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission history Published in print: 17 February 2023 Permissions Request permissions for this article. T.D.G. received research funding from Allergan Pharmaceuticals over the past 3 years.
C. David Allis (1951-2023)
Molecular biologist C. David Allis, whose discoveries ushered in a new era of epigenetics research, died on 8 January. He was 71. Allis identified enzymes that chemically modify histones, transforming our understanding of the chromatin fiber. Composed of DNA and histone proteins, chromatin was previously thought to be an inert structure, but Allis showed that it dynamically regulates DNA processes.
A shift to English in Algerian education
Information & Authors Information Published In Science Volume 379 | Issue 6633 17 February 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission history Published in print: 17 February 2023 Permissions Request permissions for this article.
In Other Journals
Protein Synthesis Gregarious ribosomes in gregarious locusts Di Jiang A solidary locust is like any other grasshopper: camouflaged to blend into the background and hopping about in search of food. However, when they are forced together by food shortage, the insects become colorful and attracted to each other. It is in this gregarious phase that locusts form swarms that can blacken the skies and obliterate crops. Many changes take place during this behavioral transition, and Li et al.
Reducing nonradiative recombination in perovskite solar cells with a porous insulator contact
LATEST NEWS Through thick but not thin To maintain high charge carrier conductivity in perovskite solar cells, the passivating layer is usually very thin (~1 nanometer) to enable electron tunneling. However, this approach limits efficiency because it creates a trade-off between open-circuit voltage and fill factor and challenges in fabricating thin films from solution over large areas. Peng et al.
Leveraging IP for AI governance
Information Published In Science Volume 379 | Issue 6633 17 February 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission history Published in print: 17 February 2023 Permissions Request permissions for this article.
In Science Journals
Neuroscience The mechanism underlying psychedelic action Peter Stern Psychedelic compounds promote cortical structural and functional neuroplasticity through the activation of serotonin 2A receptors. However, the mechanisms by which receptor activation leads to changes in neuronal growth are still poorly defined. Vargas et al.
Science and its stakeholders
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Imaging the breaking of electrostatic dams in graphene for ballistic and viscous fluids
LATEST NEWS Manipulating electron flow Electron flow in conductors becomes viscous when electron-electron collisions dominate over collisions with defects and other sources of resistance. One way to study this viscosity is by physically fabricating narrow channels for electrons to flow through, but the rough edges of such channels make comparison with theory tricky. Krebs et al. instead used electrostatics to form tunable barriers to electron flow in graphene.
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
LATEST NEWS Dendritic cells save the day Dendritic cells are a key part of the immune system and are critical for antitumor immunity because they help to induce T cell responses against tumor antigens. CD5 is a glycoprotein expressed on some immune cells, including a subset of dendritic cells, but its function had not been well understood. He et al.
A volatile sex attractant of tsetse flies
LATEST NEWS The scent of tsetse Volatile sex attractants can be used in traps to monitor and control insect spread. Tsetse flies spread disease among humans and livestock in sub-Saharan Africa, and methods for controlling them are lacking. Ebrahim et al. identified fatty acid methyl esters as the volatile sex attractants in the tsetse fly Glossina morsitans, and showed that mating behavior was promoted for male files in response to these compounds (see the Perspective by Syed).
Chemical notes of tsetse fly mating
Information & Authors Information Published In Science Volume 379 | Issue 6633 17 February 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Submission history Published in print: 17 February 2023 Permissions Request permissions for this article.
Seller’s market
eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed. Please read our Terms of Service before submitting your own eLetter.
The drivers and impacts of Amazon forest degradation
LATEST NEWS Losing the Amazon The Amazon rainforest is a biodiversity hotspot under threat from ongoing land conversion and climate change. Two Analytical Reviews in this issue synthesize data on forest loss and degradation in the Amazon basin, providing a clearer picture of its current status and future prospects. Albert et al. reviewed the drivers of change in the Amazon and show that anthropogenic changes are occurring much faster than naturally occurring environmental changes of the past.
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion
LATEST NEWS Sweat out the fat with TSLP! Thymic stromal lymphopoietin (TSLP) is a cytokine that can promote immune responses that characterize allergic diseases. Choa et al. found that mice engineered to produce elevated TSLP displayed selective white adipose tissue loss that protected them from obesity, insulin resistance, and steatohepatitis (see the Perspective by Schneider). Protection was not mediated by eosinophils, regulatory T cells, or innate lymphoid cells.
Barriers and facilitators to online medical and nursing education during the COVID-19 pandemic: perspectives from international students from low- and middle-income countries and their teaching staff
Abstract Background The COVID-19 pandemic posed a huge challenge to the education systems worldwide, forcing many countries to provisionally close educational institutions and deliver courses fully online. The aim of this study was to explore the quality of the online education in China for international medical and nursing students from low- and middle-income countries (LMICs) as well as the factors that influenced their satisfaction with online education during the COVID-19 pandemic.
Recalibrating global data center energy-use estimates
Information Published In Science Volume 367 | Issue 6481 28 February 2020 Copyright Copyright © 2020, American Association for the Advancement of Science. This is an article distributed under the terms of the Science Journals Default License. Submission history Published in print: 28 February 2020 Permissions Request permissions for this article.
When did modern humans leave Africa?
The skeletal features of our species, Homo sapiens, include a globular braincase, brow ridges that are divided into central and side portions, a flat and retracted midface, a chin on the lower jaw, and a narrow pelvis. Fossils showing many of these characteristics have been excavated from the Ethiopian sites of Omo Kibish and Herto, dated at ∼195,000 and ∼160,000 years ago, respectively (1).
Attosecond Laser Pulses Illuminate Fleeting Dance of Electrons
Like a prisoner trapped behind the wall of a fortress, an electron faces a huge barrier in escaping the confines of an atom. Yet when hit by a burst of intense light, it can set itself free in just a few hundred attoseconds (10−18 s), thanks to a quantum-mechanical phenomenon known as tunneling. In essence, it seeps through the barrier—the binding energy that normally holds it in place. Now, for the first time, scientists have seen this blindingly fast escape act happen in real time.
Filtering a River of Cancer Data
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