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Minku Song

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Articles

Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets

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By Hyeonbin Jo, Yeeun Ahn, Beomsu Kim, Injeong Shim, Soyeon Kim, Hoyoung Kim, Sanghoon Hong, Woong-Yang Park, Hong-Hee Won, Minku Song
| Nature Verified
Abstract Psoriasis is a heritable, common chronic autoimmune disorder characterized by cycles of remission and flare-ups. Here, we jointly analyze genomic and single-cell transcriptomic data to elucidate the genetic and molecular architecture of psoriasis. We perform a large-scale genome-wide meta-analysis of individuals of European ancestry (n = 1,131,685) and identify 125 independent susceptibility loci associated with psoriasis, including 17 previously unreported loci.
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