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Articles by Minta Thomas
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility - Nature Communications
Abstract Susceptibility transcription factors (TF) whose DNA bindings are altered by genetic variants regulating colorectal cancer (CRC) risk genes remain poorly defined. Using generalized linear mixed models, we analyze 218 TF ChIP-Seq datasets alongside GWAS data from 100,204 CRC cases and 154,587 controls of East Asian and European ancestries. We identify 51 TFs and TF-cofactor interactions, including VDR-cofactors, as key regulators of CRC risk.
Comparing Ancestry Standardization Approaches for a Transancestry Colorectal Cancer Polygenic Risk Score
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information References , , , et al. 1000 Genomes Project Consortium. 2015. “A Global Reference for Human Genetic Variation.” Nature 526, no. 7571: 68–74. , , , et al. Polygenic Risk Score Task Force of the International Common Disease Alliance. 2021. “Responsible Use of Polygenic Risk Scores in the Clinic: Potential Benefits, Risks and Gaps.” Nature Medicine 27, no. 11: 1876–1884. , , et al.
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations - Nature Communications
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Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.
By Minta Thomas, Elisabeth Rosenthal, Lori C. Sakoda, Stephanie Schmit, Maria Timofeeva, Ceres Fernández-Rozadilla, Philip J Law, Neil Murphy, Robert Carreras-Torres, Aesun Shin, Alicja Wolk, Andrea Gsur, Andrew Chan, Ann G. Zauber, Caroline Y. Um, Chris R. Gignoux, D. Timothy Bishop, Daniel Buchanan, Erin M. Siegel, Fredrick R. Schumacher, Gad Rennert, Graham Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jenny Chang-Claude, Jeongseon Kim, Jeroen R. Huyghe, Jiayin Zheng, Jochen Hampe, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Luis Bujanda, Mark Jenkins, Meilin Wang, Michael Hoffmeister, Mingyang Song, Mulong Du, Norie Sawada, Polly A. Newcomb, Qiuyin Cai, Robert Schoen, Robert Haile, Sergi Castellvi-Bel, Shoichiro Tsugane, Stefanie Brezina, Stephanie J Weinstein, Stephen J. Chanock, Tabitha A. Harrison, Volker Arndt, Wei-Hua Jia, Zsofia K. Stadler, Bethany Van Guelpen, Cornelia M. Ulrich, Elizabeth A. Platz, John Potter, Victor Moreno, Malcolm G. Dunlop, Stephen B. Gruber, Richard Hayes, Richard S. Houlston, Ian Tomlinson, Wei Zheng, Ulrike Peters
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Nature
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Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries | Nature Genetics
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Author notes These authors contributed equally: Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Díez-Obrero, Li Hsu. These authors jointly supervised this work: Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters.
By Ceres Fernández-Rozadilla, Maria Timofeeva, Philip J Law, Minta Thomas, Stephanie Schmit, Claire Palles, Susan M Farrington, Xingyi Guo, Peter Broderick, James B. Studd, Jeroen R. Huyghe, Tabitha A. Harrison, Christopher Dampier, Fredrick R. Schumacher, Gad Rennert, Jeongseon Kim, Min-Ho Shin, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Zefang Ren, Wei-Hua Jia, Mark Jenkins, Aung Ko Win, Robert Haile, Polly A. Newcomb, Jeremy Cheadle, Richard Kaplan, David Kerr, Pekka Jousilahti, Lauri A Aaltonen, Tatiana Cajuso, Kimmo Palin, Satu Männistö, Stephanie J Weinstein, Edward A Ruiz-Narvaez, Daniel Buchanan, Elizabeth A. Platz, Kala Visvanathan, Erin M. Siegel, Stefanie Brezina, Andrea Gsur, Jenny Chang-Claude, Michael Hoffmeister, John Potter, Konstantinos K Tsilidis, Matthias B. Schulze, Neil Murphy, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Timothy R. Bishop, Graham Giles, Melissa Southey, Bethany Van Guelpen, Thomas E Hudson, Heather Hampel, Richard Hayes, Paul Pharoah, Susanna C. Larsson, Yun Yen, Heinz-Josef Lenz, Kimberly Doheny, Andrew Chan, Amit U. Joshi, Anshul Kundaje, Robert Schoen, Jochen Hampe, Nickolas Papadopoulos, Duncan Thomas, Amanda E. Toland, Stephen J. Chanock, Edith F. Feskens, Lori C. Sakoda, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel M. FitzGerald, Shuji Ogino, Charles Kooperberg, Stéphane Bézieau, Elaine R. Mardis, Norie Sawada, Christopher A. Haiman, Gerhard A. Coetzee, Caroline Hayward, Ian J Deary, Sarah Harris, Li Yin Ooi, Victor Moreno, Ian Tomlinson, Wei Zheng, Malcolm G. Dunlop, Richard S. Houlston
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Nature
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