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Highly efficient dual-channel doublet emission in lanthanide cerium(III) complex
Abstract Dual-channel luminescent materials are attractive due to their unique electronic structures and potential applications in various fields. Different from traditional dual-channel emitters with closed-shell structure showing singlet fluorescence and/or triplet phosphorescence, we demonstrate herein dual-channel cerium(III) complexes with open-shell structure showing doublet 5d-4f emission from the central Ce(III) ion.
Development and validation of the predictive aplastic score system (PASS): a simplified tool to diagnose acquired aplastic anemia in adults
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Abstract Acquired aplastic anemia (AA) can present similarly to inherited bone marrow failure syndromes (IBMFS) but treatment differs. AA diagnosis relies on excluding IBMFS; however, genetic testing is not always available, may delay care or be inconclusive. We developed the Predictive Aplastic Score System (PASS), a clinical tool using readily available data to distinguish AA from IBMFS in adults. The training cohort included 212 adults (162 AA, 50 IBMFS).
By Gabriel Aleixo, Jiayin Zheng, Jimmy Lee, Eleonore Kaphan, Wei-Ying Jen, Mia Djulbegovic, Jairo Matthews, Tapan M Kadia, Timothy Olson, Regis de Latour, Flore Sicre de Fontbrune, Taha Bat, Courtney DiNardo, Daria V. Babushok, HeeJin Cheon, Stephanie Soewito, Neha Kalakuntla, Sumasri Kotha, Alex Rupsee
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Nature
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Controversial issues in clinical investigation of rare disease drug development
For rare disease drug development, a single-stage hypothesis testing procedure is often considered for clinical investigation regarding safety and efficacy of a test treatment study. Under the hypothesis testing framework, “p-value less than 0.05 with at least 80% power” is often used as the gold standard in the regulatory review/approval process.
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