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Miłosz Ludwinek on Muck Rack

Miłosz Ludwinek

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Articles

TTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity

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By Aneta Jurkiewicz, Agnieszka Jabłońska, Dominik Cysewski, Agata Malinowska, Magdalena Bakun, Rafał Płoski, Agnieszka Tudek, Rafał Tomecki, Małgorzata Drabko, Małgorzata Siek, Maria Matykiewicz, Miłosz Ludwinek, Kamil Kobyłecki
| Nature Verified
Abstract The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners using comparative label-free mass spectrometry. The TTC33-associated network (TAN) comprises WDR61, CCDC97, UNG1/2, PP2A-B55α, PHF5A, and components of the SF3B U2 spliceosomal complex.
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