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Miriam Bertazzon

As seen in: Nature, Cell Press
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Articles by Miriam Bertazzon

CD4 + T h immunogenicity of the Ascaris spp . secreted products

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By Miriam Bertazzon, Miguel Álvaro-Benito, Friederike Ebner, Eliot Morrison
| Nature Verified
Abstract Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines. The parasite-secreted products represent the most relevant, yet complex (>250 proteins) antigens of Ascaris spp. as defining the pathogen-host interplay. We applied an in vitro antigen processing system coupled to quantitative proteomics to identify potential CD4+ Th cell epitopes in Ascaris-secreted products.
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FBP21’s C-terminal domain remains dynamic when wrapped around the c-Sec63 unit of Brr2 helicase

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By Jana Sticht, Freie Universität Berlin, Miriam Bertazzon, Lisa M. Henning
| Cell Press Verified
Based on our recent finding that FBP21 regulates human Brr2 helicase activity involved in the activation of the spliceosomal B-complex, we investigated the structural and dynamic contribution of FBP21 to the interaction. By using NMR spectroscopy, we could show that the 50 C-terminal residues of FBP21 (FBP21 326-376), which are sufficient to fully form the interaction with the C-terminal Sec63 unit of Brr2 (Brr2 C-Sec63), adopt a random coil conformation in their unbound state.
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