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Mirjam Hanako Sarholz on Muck Rack

Mirjam Hanako Sarholz

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Articles

STING loss attenuates ISG expression without affecting PARP inhibitor sensitivity in Brca1 +/− Jak2 V617F MPN

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By Maria Rodriguez, María Rodriguez, Maria Rodríguez, María Rodríguez, Tomasz Skorski, Steffen Koschmieder, Julian Baumeister, Mirjam Hanako Sarholz
| Nature Verified
Abstract Myeloproliferative neoplasms (MPN) are characterized by constitutive activation of JAK-STAT signaling, commonly driven by the JAK2V617F mutation. Previous studies have shown that germline mutations in homologous recombination (HR) repair genes such as BRCA1 may contribute to MPN pathogenesis. We previously demonstrated that Brca1-haploinsufficiency in Jak2V617F cells induces replication stress and hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibition.
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