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Articles by Mirjam Kool
Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations - Nature Communications
Abstract CD4+ T helper 2 (Th2) cells and group 2 innate lymphoid cells are considered the main producers of type-2 cytokines that fuel chronic airway inflammation in allergic asthma. However, CD8+ cytotoxic T (Tc) cells - critical for anti-viral defense - can also produce type-2 cytokines (referred to as ‘Tc2’ cells).
MARGINAL NOTES, February 2023. Picking through the rubble
Preview this article: There is no abstract available. Received:
16/02/2023 Published Online:
21/03/2023 Keyword(s): disaster medicine , geophysical disaster , infectious disease complications of trauma and nosocomial infections © 2023 The Authors Article metrics loading... /content/journal/jmm/10.1099/jmm.0.001679 Download as PowerPoint /deliver/fulltext/jmm/72/2/jmm001679.html?itemId=/content/journal/jmm/10.1099/jmm.0.001679&mimeType=html&fmt=ahah
The foundations of aetiology: a common language for infection science
Abstract With the adoption of infection science as an umbrella term for the disciplines that inform our ideas of infection, there is a need for a common language that links infection’s constituent parts. This paper develops a conceptual framework for infection science from the major themes used to understand causal relationships in infectious diseases.
Targeting interleukin-13 in idiopathic pulmonary fibrosis: from promising path to dead end
Abstract Targeting IL-4/IL-13 with SAR156597 failed to demonstrate an effect on lung function decline for patients with idiopathic pulmonary fibrosis; these results are in line with the negative results of two other trials targeting IL-13 in this disease http://ow.ly/J0HF30mAB3J The pathogenesis of idiopathic pulmonary fibrosis (IPF) is characterised by repeated subclinical injury to the alveolar epithelium, leading to injured alveoli, myofibroblast recruitment and activation, resulting in...
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