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Bart N. Lambrecht on Muck Rack

Bart N. Lambrecht

As seen in: Color Research & Application, Nature, Wiley Online Library, ScienceDirect, Cell Reports, Cell Press, European Respiratory Journal, The Journal of Allergy & Clinical Immunology, STERCK Magazine
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Articles

The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation

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By Victor Bosteels, Sandra Maréchal, Eva Cloots, Farzaneh Fayazpour, Clint De Nolf, Simon J. Tavernier, Sofie Rennen, Seraja Amstelveen, Liesbet Martens, Delphine De Sutter, Annick Verhee, Kim Deswarte, Wouter Saelens, Louis Boon, Julie Van Duyse, Gert Van Isterdael, Isabelle Guillas, Yvan Saeys, Bruno de Geest, Sven Eyckerman, Pieter Mestdagh, Bart N. Lambrecht, Wilfried Le Goff, Sophie Janssens, Laurien Van Heddegem, Evelien Van De Velde
| Nature Verified
Abstract Conventional type I dendritic cells (cDC1s) undergo homeostatic maturation upon apoptotic cell engulfment, hallmarked by the activation of the transcription factor LXRβ, which mediates cholesterol efflux and dampens interferon-stimulated gene expression. Here, we identify the unfolded protein response sensor IRE1 as an essential regulator of this process. Loss of IRE1 impairs cDC1, but not cDC2, homeostatic maturation and survival.
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HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

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By Jean De Lima, Nivedya Swarnalekha, Claire E. Depew, Ewelina Magdalena Bartoszek, Ludivine C. Litzler, Mara Esposito, Maike Erber, Tiphaine M.N. Camarasa, Lorenzo Iseppi, Marco Künzli, Anukul T. Shenoy, Ines Lammens, Stijn Vanhee, Bart N. Lambrecht, Ananda W. Goldrath, Jie Sun, David Schreiner, Carolyn King
| Cell Press Verified
Keywords CD4 Hif1-alpha tissue lung influenza T follicular helper tertiary lymphoid structure Introduction T cell responses are initiated in draining lymphoid organs, where T cells recognize cognate antigen presented by antigen-presenting cells. Following clonal expansion, T cells migrate to non-lymphoid tissues, where they differentiate into a heterogeneous array of effectors.
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Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages

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By Stijn Verwaerde, Jean-François Hastir, Sjoerd Schetters, Ursula Smole, Leen J. M. Seys, Antonio P. Baptista, Kieran English, Martijn J. Schuijs, Helena Aegerter, Aimée Bugler-Lamb, Nikita Gerebtsov, Wendy Toussaint, Tatsuma Ban, Tomohiko Tamura, Florent Ginhoux, Zhaoyuan Liu, Wouter Saelens, Hamida Hammad, Martin Guilliams, Bart N. Lambrecht
| Cell Press Verified
Keywords asthma type 2 immunity alveolar macrophage macrophage niche PPARγ IRF4 ILC2 multinucleated giant cell chemokines alternatively activated macrophages Get full text access Log in, subscribe or purchase for full access. References 1. Guilliams, M. ∙ Thierry, G.R. ∙ Bonnardel, J. ... Establishment and Maintenance of the Macrophage Niche Immunity. 2020; 52:434-451 2. Hashimoto, D. ∙ Chow, A. ∙ Noizat, C. ...
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