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Bart N. Lambrecht on Muck Rack

Bart N. Lambrecht

As seen in: Color Research & Application, Nature, Wiley Online Library, ScienceDirect, Cell Press, Cell Reports, European Respiratory Journal, The Journal of Allergy & Clinical Immunology, STERCK Magazine
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Articles

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

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By Anneloes van Krimpen, Julie Huang, Vivian I.V. Gerretsen, Michihisa Umetani, Menno van Nimwegen, Nina E.M. Rozendaal, Thierry van den Bosch, Xinguo Jiang, Angela Liu, Yun-Ru Liu, Yuki Nagasaki, Makoto Murakami, Anne Onrust-van Schoonhoven, Disha Vadgama, Rogier T. A. van Wijck, Eric Bindels, Jan H. von der Thüsen, Antien L. Mooyaart, Febe van Maldegem, Stijn Verwaerde, Rudi W. Hendriks, Bart N. Lambrecht, Dirk J. Grünhagen, Cornelis Verhoef, Joachim G. J. V. Aerts, kan lu, Ralph Stadhouders, Floris Dammeijer, Mike Eterman, Josephine C. Janssen, Kathryn Logronio, Asabi Leliveld, Hedwig Langeveld, Claudia M. Brenis, Li-Fen Lee
| Nature Verified
Abstract Systemic anti-tumour immunity results from T cell priming in tumour-draining lymph nodes (TDLNs)1,2,3,4. Although the suppression of T cells in tumours is well characterized5,6,7,8, whether this occurs in TDLNs—and if so, through which mechanisms—remains poorly understood. Here, using imaging mass cytometry of TDLNs from patients with melanoma, we identify a spatial neighbourhood in the TDLN paracortex that is linked to the development of distant metastases.
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The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation

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By Victor Bosteels, Sandra Maréchal, Eva Cloots, Farzaneh Fayazpour, Clint De Nolf, Simon J. Tavernier, Sofie Rennen, Seraja Amstelveen, Liesbet Martens, Delphine De Sutter, Annick Verhee, Kim Deswarte, Wouter Saelens, Louis Boon, Julie Van Duyse, Gert Van Isterdael, Isabelle Guillas, Yvan Saeys, Bruno de Geest, Sven Eyckerman, Pieter Mestdagh, Bart N. Lambrecht, Wilfried Le Goff, Sophie Janssens, Laurien Van Heddegem, Evelien Van De Velde
| Nature Verified
Abstract Conventional type I dendritic cells (cDC1s) undergo homeostatic maturation upon apoptotic cell engulfment, hallmarked by the activation of the transcription factor LXRβ, which mediates cholesterol efflux and dampens interferon-stimulated gene expression. Here, we identify the unfolded protein response sensor IRE1 as an essential regulator of this process. Loss of IRE1 impairs cDC1, but not cDC2, homeostatic maturation and survival.
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HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

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By Jean De Lima, Nivedya Swarnalekha, Claire E. Depew, Ewelina Magdalena Bartoszek, Ludivine C. Litzler, Mara Esposito, Maike Erber, Tiphaine M.N. Camarasa, Lorenzo Iseppi, Marco Künzli, Anukul T. Shenoy, Ines Lammens, Stijn Vanhee, Bart N. Lambrecht, Ananda W. Goldrath, Jie Sun, David Schreiner, Carolyn King
| Cell Press Verified
Keywords CD4 Hif1-alpha tissue lung influenza T follicular helper tertiary lymphoid structure Introduction T cell responses are initiated in draining lymphoid organs, where T cells recognize cognate antigen presented by antigen-presenting cells. Following clonal expansion, T cells migrate to non-lymphoid tissues, where they differentiate into a heterogeneous array of effectors.
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