Mithila Sawant

Information Published In Science Translational Medicine Volume 14 | Issue 649 June 2022 Copyright Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License. Submission history Received: 13 January 2022 Accepted: 17 May 2022 Permissions Request permissions for this article.

A gut reaction Abstract Supplementary Materials REFERENCES AND NOTES A gut reaction Newborn infants exposed to perinatal antibiotics have an increased likelihood of developing pneumonia. Here, Stevens and colleagues characterized the effects of dysbiosis of the intestinal microbiota on pulmonary immune responses in newborn rhesus macaques.

DISCUSSION In this report, we uncover a dual-modified AR engendered by cancer cells to maintain high AR and ACK1, overcoming the effect of AR antagonists. Because of successive deposition of these modifications and their interdependence, targeting the earliest event, AR Y267 phosphorylation, using an ACK1 kinase inhibitor not only suppressed AR K609 acetylation but also caused a global shutdown of many critical genes, including AR and ACK1.