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Articles by Mitro Miihkinen
Estimating the completeness of large-scale single-cell sequencing projects
Abstract During embryonic development, cells undergo differentiation into highly specialized cell types. Capitalizing on single-cell RNA sequencing, many initiatives and substantial resources are cataloguing these differentiated cell types by their transcriptomic profiles. Despite the extensive efforts to profile various organs and their cellular compositions, we lack metrics to assess the completeness of the sequencing projects.
Discovery of predictive biomarkers for cancer therapy through computational approaches - Nature Reviews Clinical Oncology
Abstract Precision oncology involves the use of predictive biomarkers to personalize treatment. However, for most cancer therapeutics or combination regimens, effective biomarkers have been elusive. This challenge has fuelled efforts to interrogate increasingly diverse and complex clinical and molecular determinants of treatment response.
Discovery of predictive biomarkers for cancer therapy through computational approaches
7 hours ago Before heading to speak at this week’s Consumer Electronics Show (CES) in Las Vegas, I found myself lingering longer than usual in stores like Best Buy and Apple. CES is where the tech industry unveils its vision of the future, but retail stores reveal what consumers are actually buying. And what …
Computational drug repurposing: approaches, evaluation of in silico resources and case studies - Nature Reviews Drug Discovery
Abstract Repurposing of existing drugs for new indications has attracted substantial attention owing to its potential to accelerate drug development and reduce costs. Hundreds of computational resources such as databases and predictive platforms have been developed that can be applied for drug repurposing, making it challenging to select the right resource for a specific drug repurposing project.
Estimating the completeness of large-scale single-cell sequencing projects
Abstract During embryonic development, cells undergo differentiation into highly specialized cell types. Capitalizing on single-cell RNA sequencing, substantial resources have been invested towards cataloguing these differentiated cell types by their transcriptomic profiles. Despite the extensive efforts to profile various organs and their cellular compositions, we lack metrics to assess the completeness of the sequencing projects.
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation
Supporting Information Filename Description path6405-sup-0001-SuppMatMethFiguresS1-S8TableS1.docxWord 2007 document , 14.3 MB Supplementary materials and methods Figure S1. GeoMx sample slide preparation Figure S2. Sample re-grouping Figure S3. UMAP plots according to the patient and medication status Figure S4. Tissue staining of ANO7 and immune cells Figure S5. Network analysis Figure S6. ANO7 expression in TCGA PRAD bulk RNA-seq per sample group Figure S7. Immune cell analysis Figure S8.
Completeness estimation of large-scale single-cell sequencing projects
Abstract During embryonic development, cells undergo differentiation into highly specialized cell types. Taking advantage of single-cell RNA sequencing, substantial resources have been invested towards cataloguing these differentiated cell types by their transcriptomic profiles. Despite the extensive efforts to profile different organs and their cellular compositions, metrics to assess the completeness of such datasets have been lacking.
SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
Highlights • SHANK3 binds actin directly • Conformational switch regulates and promotes SHANK3 binding to actin • Actin filaments and active Rap1 compete for interactions with SHANK3 • SHANK3-actin interaction regulates autism-linked phenotypes in vivo Summary Actin-rich cellular protrusions direct versatile biological processes from cancer cell invasion to dendritic spine development.
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