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Mmatsie Manentsa

As seen in: Nature
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Articles

Viral variant but not host factors associate with SARS-CoV-2 viral kinetics

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By William Hahn, Amy Ward, Shannon Grant, Catherine Yen, April Kaur Randhawa, Xiaohong Li, Shelly Anne Ramirez, John Hural, Pavitra Roychoudhury, Colleen Kelley, Nadine Rouphael, Valeria D. Cantos, Jorge A. Pinto, Pedro Cahn, Joseph Makhema, Lynda Stranix-Chibanda, Marcelo H. Losso, Craig Innes, Lameck Chinula, Javier R. Lama, Roma Chilengi, Maphoshane Nchabeleng, Hong-Van Tieu, Brenda Hoagland, Beatriz Grinsztejn, William Brumskine, Khatija Ahmed, Carole L Wallis, Alexander L. Greninger, Lawrence Corey, Ollivier Hyrien, Leigh H. Fisher, Nicole Espy, Jennifer Hanke, Mmatsie Manentsa, Wadzanai Samaneka, Muchaneta Bhondai-Mhuri, Jorge A. Gallardo-Cartagena, Chishiba Kabengele
| Nature Verified
Abstract It is challenging to assess SARS-CoV-2 viral kinetics amidst viral variant evolution and changes in population-level immunity. However, understanding the relationship between host factors and viral replication deepens our understanding of viral fitness. In CoVPN 5001, we enrolled N = 953 adults diagnosed with acute SARS-CoV-2 from July 2020 to July 2022 across 51 sites. We confirmed SARS-CoV-2 infection by RT-PCR and identified the variant via viral genome sequencing.
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