Modestas Matusevicius on Muck Rack

Modestas Matusevicius

As seen in: eLife
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Articles

Insights from aquaporin structures into drug-resistant sleeping sickness

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By Modestas Matusevicius, Robin A. Corey, Marcos Gragera, Keitaro Yamashita
| eLife
eLife Assessment In this important study, the authors set out to determine the molecular interactions between the AQP2 from Trypanosoma brucei (TbAQP2) and the trypanocidal drugs pentamidine and melarsoprol to understand how TbAQP2 mutations lead to drug resistance.
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Insights from aquaporin structures into drug-resistant sleeping sickness

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By Robin A. Corey, Marcos Gragera, Keitaro Yamashita, Modestas Matusevicius
| biorxiv.org
Abstract Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentamidine and melarsoprol through mutations in the aquaglyceroporin TbAQP2 that prevent their uptake.
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