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A system-based analysis of the genetic determinism of udder conformation and health phenotypes across three French dairy cattle breeds

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By Andrew Marete, Mogens Sandø Lund, Didier Boichard
| PLOS
Using GWAS to identify candidate genes associated with cattle morphology traits at a functional level is challenging. The main difficulty of identifying candidate genes and gene interactions associated with such complex traits is the long-range linkage disequilibrium (LD) phenomenon reported widely in dairy cattle. Systems biology approaches, such as combining the Association Weight Matrix (AWM) with a Partial Correlation in an Information Theory (PCIT) algorithm, can assist in overcoming this LD.
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