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Mohak Sharda

As seen in: Medium, PLOS Biology, BioRxiv
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Articles

The evolution of sequence specificity in a DNA binding protein family

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By Meghna Nandy, Mohak Sharda, Madhumitha Krishnaswamy
| BioRxiv
Abstract Transcriptional regulation enables bacteria to adjust to its environment. This is driven by transcription factors (TFs), which display DNA site recognition specificity with some flexibility built in. TFs, however, are not considered essential to a minimal cellular life. How do they evolve? It has been hypothesized that TFs evolve by gaining specificity (and other functions) on a background of non-specific chromosome structuring proteins.
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The evolution of sequence specificity in a DNA binding protein family

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By Meghna Nandy, Mohak Sharda
| BioRxiv
Abstract Transcriptional regulation enables bacteria to adjust to its environment. This is driven by transcription factors (TFs), which display DNA site recognition specificity with some flexibility built-in. TFs however are not considered essential to a minimal cellular life. How do they evolve? It has been hypothesised that TFs evolve by gaining specificity (and other functions) on a background of non-specific chromosome structuring proteins.
Open in Who Shared Issue with article?

Widespread prevalence of a methylation-dependent switch to activate an essential DNA damage response in bacteria

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By Aditya Kamat, Ngat T. Tran, Colney Lane, Mohak Sharda
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Kamat A, Tran NT, Sharda M, Sontakke N, Le TBK, Badrinarayanan A (2024) Widespread prevalence of a methylation-dependent switch to activate an essential DNA damage response in bacteria. PLoS Biol 22(3): e3002540.
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