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Mohamed ElGhazaly

As seen in: Wiley Online Library, Cell Reports
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Articles by Mohamed ElGhazaly

Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection

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By Mohamed ElGhazaly, Mark Collins, Daniel Humphreys, Angela E.M. Ibler
| Cell Reports Verified
Highlights • Salmonella co-opts Wnt5a, INHBA, and GDF15 secreted from toxin-induced senescent cells • Wnt5a suppresses apoptosis, establishing senescence in response to typhoid toxin • Wnt5a and INHBA synergize, causing paracrine senescence in bystander cells • Salmonella hijacks secreted factors Wnt5a and GDF15 to enhance host cell invasion Summary Damage to our genome causes acute senescence in mammalian cells, which undergo growth arrest and release a senescence-associated secretory...
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Molecular Microbiology | Microbiology Journal | Wiley Online Library

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By Mohamed ElGhazaly
| Wiley Online Library Verified
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