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Mohammad Esmail Akbari on Muck Rack

Mohammad Esmail Akbari

As seen in: Nature
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Articles

Harnessing nanomedicine for breast cancer therapy through the immunomodulatory activity of BCc1

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By Ali Salimi, Saideh Fakharzadeh, Maryam Hafizi, Mohammad Hassan Nazaran, Mehrdad Hashemi, Fereshteh Moheb Afzali, Masoumeh Heshmati, Somayeh Kalanaky, Mohammad Esmail Akbari
| Nature Verified
Abstract Although BCc1 represents a novel nanochelating-based nanomedicine, its route- and dose-dependent impacts on mammary oncogenesis, immunoregulation, and non-coding RNA (ncRNA) dynamics remain poorly defined. Here, female BALB/c mice bearing subcutaneous 4T1 mammary carcinomas were treated with oral or intraperitoneal BCc1 at diverse doses for 24 days. BCc1 restricted primary tumor kinetics in a dose- and route-dependent manner without compromising systemic tolerability or body weight.
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