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Mohammad Sanaei Ardekani on Muck Rack

Mohammad Sanaei Ardekani

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Articles

Association of Three HIF-1α Genotypes With Susceptibility and Severity of Chronic Kidney Disease

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By Hanifa Aktar, Shahrzad Ashena, Mohammad Sanaei Ardekani
| Wiley Online Library Verified
1 Introduction Hypoxia plays a critical role in the pathogenesis of kidney failure. The kidney medullary tissue, which is naturally hypoxic with PO2 of 10–20 mmHg, is highly sensitive to drops in O2 pressure. In addition, tubular cells, due to ATP-requiring active transport, have a high O2 demand. Such features make kidney tissue extremely susceptible to low oxygen tension.
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