Mohit Dhiman

Cooperativity in the assembly of H-bonded duplexes of synthetic recognition-encoded melamine oligomers† Recognition-encoded melamine oligomers (REMO) are synthetic polymers composed of repeating triazine–piperazine units and equipped with phenol and phosphine oxide side-chains. Short oligomers have previously been shown to form length- and sequence-selective H-bonded duplexes in non-polar solvents.

1. Introduction Click to copy section linkSection link copied! Template-directed synthesis is the basis of DNA replication and governs the transmission of biological inheritance and the expression and regulation of biological function in nature. (1,2) Soon after the discovery of the structure of DNA and the mechanism of DNA replication, Todd envisaged that chemists would emulate nature and use the principles of template-directed synthesis in organic chemistry.

Sequence-selective pulldown of recognition-encoded melamine oligomers using covalent capture on a solid support† The covalent capture of recognition-encoded melamine oligomers (REMO) with a target attached to a solid support was investigated. Sequence-selective pulldown of complementary oligomers was observed when the target was challenged with a randomised library of oligomers. The approach provides an affinity selection method for the discovery of functional REMO sequences.