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Articles by Molecular Sciences
Stitching Organelles: Organization and Function of Specialized Membrane Contact Sites in Plants
The coordination of multiple metabolic activities in plants relies on an interorganelle communication network established through membrane contact sites (MCS). The MCS are maintained in transient or durable configurations by tethering structures which keep the two membranes in close proximity, and create chemical microdomains that allow localized and targeted exchange of small molecules and possibly proteins.
Functional Characterization of Schizophrenia-Associated Variation in CACNA1C
Citation: Eckart N, Song Q, Yang R, Wang R, Zhu H, McCallion AS, et al. (2016) Functional Characterization of Schizophrenia-Associated Variation in CACNA1C. PLoS ONE 11(6): e0157086. doi:10.1371/journal.pone.0157086 Copyright: © 2016 Eckart et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Confinement-Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
Differential Modulation of PKA Activity Is Required for Optimized Migration of CHO-α4WT Cells through Unconfined versus Confined Spaces Elevated Intracellular Calcium in Confined Cells Negatively Regulates PKA via Piezo1 and PDE1 Inhibition of Piezo1 and Myosin II Synergistically Abrogates Confinement-Induced Enhancement of Cell Stiffness To test the hypothesis that PKA activity is differentially regulated in unconfined versus confined spaces, we utilized a FRET-based PKA activity biosensor,...
Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes
Co-expression analysis has been employed to predict gene function, identify functional modules, and determine tumor subtypes. Previous co-expression analysis was mainly conducted at bulk tissue level. It is unclear whether co-expression analysis at the single-cell level will provide novel insights into transcriptional regulation. Here we developed a computational approach to compare glioblastoma expression profiles at the single-cell level with those obtained from bulk tumors.
New Cysteine-Rich Ice-Binding Protein Secreted from Antarctic Microalga, Chloromonas sp.
Citation: Jung W, Campbell RL, Gwak Y, Kim JI, Davies PL, Jin E (2016) New Cysteine-Rich Ice-Binding Protein Secreted from Antarctic Microalga, Chloromonas sp. PLoS ONE 11(4): e0154056. doi:10.1371/journal.pone.0154056 Copyright: © 2016 Jung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Control of chemical reactivity by transition-state and beyond
It has been long established that the transition state for an activated reaction controls the overall reactivity, serving as the bottleneck for reaction flux. However, the role of the transition state in regulating quantum state resolved reactivity has only been addressed more recently, thanks to advances in both experimental and theoretical techniques.
Recent advances in dye-sensitized semiconductor systems for photocatalytic hydrogen production
Photocatalytic water splitting by solar light has received tremendous attention for the production of clean and renewable hydrogen energy from water. Some challenges still remain in improving the solar-to-hydrogen energy conversion efficiency, such as utilizing longer-wavelength photons and enhancing the photocatalytic activity and stability of H production over semiconducting materials.
Using modified aptamers for site specific protein-aptamer conjugations
Conjugation of DNA to defined locations on a protein surface will be a powerful tool for positioning functional groups and molecules in biological and biomedical studies. However, tagging protein with DNA is challenging in physiological environments, and requires a bioorthogonal approach. Here, we report a chemical solution to selectively conjugate DNA aptamers with a protein by protein–aptamer template (PAT)-directed reactions.
Fluorescent turn-on probes for the detection of fluoride ions in organic solvent and in cells
We have successfully developed two coumarin-based fluorescent probes to detect F in vitro. Probe 1 is lipophilic for organic soluted detection. Probe 2 is an amphipathic molecule due to its TBDPS and triphenyl-phosphine groups for both mitochondrial localization and fluoride ion detection. Both of the two probes have good selectivity in F detection; the detection limit of probe 2 was as low as 670 nM. Probe 2 has good fluorescence enhancement in response to F in cell imaging.
Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing
a Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China E-mail: xbzhang@hnu.edu.cn b Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute,...
N 6-Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens
N -Methyladenine (m A) is the most abundant internal modification on mammalian mRNA. Very recently, m A has been reported as a potentially important ‘epigenetic’ mark in eukaryotes. Until now, site-specific detection of m A is technically very challenging. Here, we first reveal that m A significantly hinders DNA- and RNA-directed DNA synthesis. Systematic investigations of 5′-triphosphates of a variety of 5-substituted 2′-deoxyuridine analogs in primer extension have been performed.
Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications
Hydrogels are crosslinked hydrophilic polymers that can absorb a large amount of water. By their hydrophilic, biocompatible and highly tunable nature, hydrogels can be tailored for applications in bioanalysis and biomedicine. Of particular interest are DNA-based hydrogels owing to the unique features of nucleic acids. Since the discovery of the DNA double helical structure, interest in DNA has expanded beyond its genetic role to applications in nanotechnology and materials science.
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