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Moloud Akbarzadeh on Muck Rack

Moloud Akbarzadeh

As seen in: BioRxiv
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Articles

An Itch Receptor Drives Melanoma

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By Naina Gour, Aishwarya Atakkatan, Moloud Akbarzadeh
| BioRxiv
Abstract Mas-Related GPCR X4 (MRGPRX4) is a sensory neuron-restricted receptor for cholestatic itch. Here, we identify MRGPRX4 as an unexpected melanoma driver. MRGPRX4 is upregulated in melanoma and is confined to invasive, neural-crest-like and pre-EMT states associated with dedifferentiation and therapy resistance. Ectopic MRGPRX4 expression in mouse melanocytes drives 100% penetrant, highly metastatic melanoma, demonstrating oncogenic behavior.
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