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Monah Abou Alezz on Muck Rack

Monah Abou Alezz

As seen in: Nature, BioRxiv
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Articles

AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain - Nature Communications

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By Vasco Meneghini, Monah Abou Alezz, Xin Huang, Silvia Piccolo, Roberta Caccia, Bérangère Bertin, Giuseppe Ronzitti, Helena Costa-Verdera, Giovanni Crivicich, Ivan Cuccovillo, Angela Gritti
| Nature Verified
Abstract Adeno-associated viral (AAV) vector-based gene therapy is gaining foothold as treatment for genetic neurological diseases with encouraging clinical results. Nonetheless, dose-dependent adverse events have emerged in recent clinical trials through mechanisms that remain unclear. We have modelled here the impact of AAV transduction in cell models of the human central nervous system (CNS), taking advantage of induced pluripotent stem cells.
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CD32 allows capturing blood cells emergence in slow motion during human embryonic development

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By Rebecca Scarfo, Monah Abou Alezz, Mahassen El Khoury, Amelie Gersch
| BioRxiv
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